From Johannesburg head north on the N1 towards the N4 Toll road.
Take the N4 Toll road north west towards Rustenburg, Swartruggens, Groot Marico and Zeerust.
Once in Zeerust turn right at the second stop street into President Street. There is a signpost on the left. that says "Madikwe Game Reserve/Gaborone" and a First National Bank on the corner to the right.
Follow the R49 towards the reserve for approximately 97km.
The first entrance to the reserve is Abjaterskop Gate.
The second gate to the reserve is the Wonderboom Gate exactly 7km from the first gate.
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